Center for Advancing Systems Science and Bioengineering Innovation (CASSBI) takes on a new focus

Marvel superheroes use their superpowers to leap tall buildings and break through walls. Heroes at George Mason University's Center for Advancing Systems Science and Bioengineering Innovation (CASSBI) heroes use their "superpowers" to break through disciplinary silos and improve human health.

“It’s very unique the way CASSBI brought so many disciplines together,” said Amy Adams, executive director of the Institute for Biohealth Innovation. “Their human-centered approach has attracted faculty from all over the university, leveraging the expertise from so many fields of study.” 

CASSBI leaders have always understood research efforts don’t take place in a vacuum—the more collaboration, the better. And since its inception in 2019, CASSBI has leveraged faculty from disciplines as diverse as mathematics and social work, or kinesiology and mechanical engineering, all to improve human health.  

Professors Siddhartha Sikdar and Parag Chitnis, both from the Bioengineering Department in the College of Engineering and Computing, are co-leaders of the center that recently refreshed its mission and zeroed in more tightly on its translational research. They say that the new vision of CASSBI is advancing system science and integrating innovation with medical technologies. 

“Our work has always been translational,” said Sikdar, “In our earlier version, the translational focus was more on centering the priorities of our community partners and addressing their needs through research and creating and disseminating tools that would benefit them directly right now. For example, one success story is a nonprofit we created called iConnect, which works with our community partners to support individuals in recovery from substance misuse. Now we are also working on supporting translation of technologies from the lab to the marketplace, and we will prioritize that equally," he said. 

The center will emphasize spin-offs and start-ups from the technology developed at CASSBI in addition to community-engaged research. 

Sikdar and Chitnis are off to a good start with a new company that grew out of a Department of Defense grant on tendon and joint injury prevention and reduction using wearable ultrasound systems. In this case, the researchers saw that what they had developed for the military had a broader use and could improve more people's lives by marketing it to a civilian population. 

“We’re trying to pursue research of consequence in a way where we are trying to understand the entire pipeline A-Z and how the activities that can be pursued at the academic level and the research lab or center level can eventually be brought to real world,” said Sikdar. 

To the CASSBI team, this means all aspects of translation including preclinical, translational studies, clinical trials, commercialization, development of patents, and intellectual property.  

Another important aim for CASSBI is to create a support structure for faculty, staff, and researchers to engage in these additional activities. Sikdar and Chitnis want to build out the enhanced support system for devise fabrication, and for navigating the regulatory pathway when working with federal agencies, or for obtaining grant funding that is not traditional academic grants. “We’re becoming more geared towards translational, entrepreneurial, and industrial activities,” said Chitnis. 

Chitnis summarizes the new direction: "We're looking at a more holistic approach and how the impact of our science, research, and development can be felt outside of the university.”